: patrisrilakshmi@nitw.ac.in : 8332969498
Research Interests: Bio-organic Chemistry, Medicinal Chemistry, Drug Delivery and Gene Delivery
Specializations : Design, Synthesis and Biological Evaluation of Non-Viral Gene Delivery Vectors
Message
Course Taught Previously
Academic Year | Semester | Classes | Course ID | Course Name |
2006-2007 | 1 & 2 | B.Tech | CY-101 | Chemistry |
2007-2008 | 1 & 2 | B.Tech | CY- 101 | Chemistry |
2008-2009 | 1 & 2 | B.Tech | CY-101 | Chemistry |
2009-2010 | 1 & 2 | B.Tech | CY-101 | Chemistry |
2010-2011 | 1 & 2 | B.Tech | CY - 101 | Chemistry |
| 2012-2015 | 1 & 2 | B.Tech | CY-101 | Chemistry |
| 2015-2017 | 1 | B.Tech | CY-101 | Chemistry |
2006-2007 | 4 | M.Sc | Bio-organic Chemistry | |
2007-2008 | 4 | M.Sc | Bio0organic Chemistry | |
2008-2009 | 4 | M.Sc | Bio-Organic Chemistry | |
2009-2010 | 4 | M.Sc | Bio-organic Chemistry | |
| 2011-2017 | 4 | M.Sc | CY-6152 | Bio-organic Chemistry |
2009-2010 | 2 | II B. Tech | Cy-252 | Advanced Organic Chemistry |
2010-2011 | 2 | IIBtech | CY-252 | Advanced Organic Chemistry |
2006-2007 | 3 | M.Sc | CY-604 | Chemistry of Natural Products |
2007-2008 | 3 | M.Sc | CY-604 | Chemistry of Natural Products |
2008-2009 | 3 | M.Sc | CY-604 | Chemistry of Natural Products |
2009-2010 | 3 | M.Sc | CY-604 | Chemistry of Natural Products |
2010-2011 | 3 | M.Sc | CY-604 | Chemistry of Natural Products |
| 2012-2017 | 3 | M.Sc | CY-6112 | Chemistry of Natural Products |
Courses Currently Being Taught
Classes | Department | Semester | Course ID | Course Name |
I-Btech | Chemistry | 1 | CY-101 | Chemistry |
M.Sc | Chemistry | 3 | CY-6112 |
|
| M.Sc | Chemistry | 2 | CY-5111 | Chemistry of Heterocyclics and Biomolecules |
Journal Publication Details
Author | Title | Journal Name | Vol. Page. Year. |
Srilakshmi V. Patri*, Venkanna Muripiti, Brijesh Lohchania , Venkatesh Ravula, Shireesha Manturthi, Srujan Marepally, Amarnath Velidandi. | Dramatic Influence of Hydroxy Functionality of Azasugar Moiety in the Head Group Region of Tocopherol Based Cationic Lipids on the In-vitro Gene Transfection Efficacies. | New Journal of Chemistry
| (Under Revision). |
| Venkanna Muripiti, Ramesh Gondru, V. Patri*.
| Review of Zinc (II) scaffolds: Efficient role in gene delivery. | Chemistry Select | (Accepted). |
| Srilakshmi Patri*, Amarnath Velidandi, Venkanna Muripiti, Venkatesh Ravula, Shireesha Manturthi. | An assortment of Thiazines Preparation methods and Applications: A review. | Medicinal Chemistry Research | Submitted |
| Venkanna Muripiti, Thasneem Yoosuf Mujahid, Venkata Harsha Vardhan Boddeda, Shrish Tiwari, Srujan Kumar Marepally, Srilakshmi V Patri, Vijaya Gopal, | Structure-activity relationship of serotonin derived tocopherol lipids. | International Journal of Pharmaceutics | 2018 554: 134-148 |
| Venkanna Muripiti, Hari Krishnareddy Rachamalla, Rajkumar Banerjee, V Patri*. | a-Tocopherol-based cationic amphiphiles with a novel pH sensitive hybrid linker for gene delivery. | Organic & Biomolecular Chemistry, | 2018, 16, 2932 - 2946. |
| Venkanna Muripiti, Brijesh Lohchania, Hari KrishnaReddy Rachamalla, Srujan Kumar Marepally, Rajkumar Banerjee and Srilakshmi V. Patri*. | Tocopherol-ascorbic acid hybrid antioxidant based cationic amphiphile for gene delivery: Design, Synthesis and transfection. | Bio-Organic Chemistry,2 | 2019,82,178-191. |
| Venkanna Muripiti, Brijesh Lohchania, Srujan Kumar Marepally and Srilakshmi V. Patri*. | Hepatocellular targeted α-tocopherol based pH sensitive galactosylated lipids: design, synthesis and transfection studies. | Chem. Commun., | 2018,9, 264-274 |
Mallikarjun Gosangi, Hithavani Rapaka, Venkatesh Ravula, and Srilakshmi V. Patri. | Evolution of New â??Bolaliposomesâ?? using Novel α-Tocopheryl Succinate Based Cationic Lipid and 1,12-Disubstituted Dodecane-Based Bolaamphiphile for Efficient Gene Delivery. | Bioconjugate chemistry | 2017, 28(7), 1965â??1977. |
Mallikarjun Gosangia, Hithavani Rapakaa, Thasneem Yoosuf Mujahidb, Srilakshmi Patri*. | Novel 1, 2, 3-Triazolium Based Dicationic Amphiphiles Synthesized by using Click-chemistry Approach for Efficient Plasmid Delivery. | MedChemComm. | 2017, 8, 989-999. |
Mallikarjun Gosangi, Thasneem Yoosuf Mujahid, Vijaya Gopal and Srilakshmi V. Patri. , | Eï¬?ects of heterocyclic-based head group modiï¬?cations on the structureâ??activity relationship of tocopherol-based lipids for non-viral gene delivery. | Org. Biomol. Chem. | 2016, 14, 6857. |
Velidandi Amarnath, Prasanna Bethanamudi, Gadidasu Kranthi Kumar and Patri V Srilakshmi. | Design, Synthesis and Anti-cancer Activity of Novel Dihydropyrazole and Benzothiazole Conjugates. | Research Journal of Pharmaceutical, Biological and Chemical Sciences. | 2016, 7(3), 29-39. |
Velidandi Amarnath, Gadidasu Kranthi Kumar and Patri V Srilakshmi. | Design, Synthesis and Evaluation of Novel Benzoxazole, Benzimidazole and Benzthiazole Based Cationic Lipids as Anticancer agents. | Research Journal of Pharmaceutical, Biological and Chemical Sciences. | 2015, 6(4), 404-418. |
Kedika Bhavani, Patri V Srilakshmi.
| Benzothiazole Head-group Based Cationic Lipids: Synthesis and Applications for Gene Delivery. | Eur. Jour. of Med. Chem. | 2014, 74,703-706. |
Kedika Bhavani, Srilakshmi V Patri. | Synthesis and Gene Transfer Activities of Novel Serum Compatible Reducible Tocopherol- Based Cationic Lipids. | Molecular Pharmaceutics | 2012, 9, 1146â??1162. |
Kedika Bhavani, Srilakshmi V Patri. | The influence of minor backbone structural variations in modulating the in vitro gene transfer efficacies of tocopherol based cationic transfection lipids. | Bioconjugate Chem. | 2011, 22(12), 2581-2592. |
Bhavani Kedika and Srilakshmi V Patri. | Design, Synthesis and In Vitro Transfection Biology of Novel Tocopherol Based Mono-cationic Lipids: A Structure-Activity Investigation. | J. Med. Chem. | 2011, 54(2), 548-561 |
Velidandi Amarnath, Gadidasu Kranthi Kumar and Patri V Srilakshmi. | Synthesis of novel porphyrin based lipids and their anti bacterial activity. | Medicinal Chemistry Research | In Press |
Jeremy A. Bumer, Marquita M. Qualis, H. Dorota Inerowicz, Robert H. Haynes, V. Srilakshmi, | Cytoplasmic delivery of liposomal contents mediated by and acid-labile cholesterol-venyl ether- PEG conjugate. | Bio-conjugate Chemistry | 2009,20,47-59 |
Gollapudi Venkata Srilakshmi, Joyeeta Sen, Arabinda Chaudhuri, Yerramsetti Ramadas, Nalam Madhus | Anchor-Dependent Lipofection with Non-Glycerol based Cytofectins containing Single 2-Hydroxyethyl Head Groups. | Biochim. Biophys. Acta. (Biomembranes ) | 2002, 1559, 87-95 |
Gollapudi Venkata Srilakshmi and Arabinda Chaudhuri. | "Snap-Shooting" the Interface of AOT reverse micelles: Use of chemical trapping. | Chem. Eur. J. | 2000, 6, 2847-2853. |
Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao and | A novel series of Non-glycerol based cationic transfection lipids for use in liposomal gene delivery. | J. Med. Chem. | 1999, 42, 4292-4299. |
Prasanta Kumar Das, Gollapudi Venkata Srilakshmi and Arabinda Chaudhuri. | Experimental probing of water and counterion concentrations inside a reversed micelle water-pool: An overlooked parameter in micellar enzymology. | Langmuir | 1999, 15, 981-987 |
Conference Proceeding
Author | Title | Conference Name | Vol. Page. Year. |
Kedika Bhavani, Patri Venkata Srilakshmi | Design and synthesis of novel non_viral gene delivery vectors using natural products | Asian Symposium on Medicinal Plants, Species and other Natural Products (ASOMPS)XIII-2008 | 2008 |
Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao and Arab | A Novel Series of Non-Glycerol based Cationic Transfection Lipids for use in Liposomal Gene Delivery | 2nd National Symposium in Chemistry | 2000, page 114 |
R. Banerjee, P. K. Das, G. V. Srilakshmi, N. M. Rao and Arabinda Chaudhuri | A Novel Series of Non-Glycerol based Cationic Transfection Lipids for use in Liposomal Gene Delivery. | Fifth International Symposium on Bio-Organic Chemistry (ISBOC-5) | 2000, page 78. |
Gollapudi Venkata Srilakshmi, Prasanta Kumar Das and Arabinda Chaudhuri | On the Anisotropic Interfaces of Membrane Mimetic Surfactant Assemblies. | International Symposium on Bio-Organic Chemistry | 2000 |
Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao and Ara | Novel Cationic Transfection Lipids for use in Liposomal Gene Delivery | EIGHTH NATIONAL ORGANIC SYMPOSIUM TRUST (NOST | 2000 |
Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana R | Novel Cationic Transfection Lipids for use in Liposomal Gene Delivery. | 13th International Symposium on Surfactants in Solution (SIS-2000) | 2000, page 206. |
Ph.D.'s Supervised
Candidate | Thesis | Award Year |
K. Bhavani | Awarded | |
V. Amarnath | Awarded | |
G.Mallikarjun | Awarded | |
| M. Venkanna | Awarded | |
| R. Hithavani | Soon Submitting Synopsis | |
| R. Venkatesh | In Progress | |
| M. Shirisha | In Progress |
Workshop/SSTPs/Conference Attended
Title | Date | Workshop | Organized At |
National Symposium on Recent Trends in Organic and Medicinal Chemistry | Jan 16-17, 2009 | Conference | NITW |
Gorden Conference on Supra-molecules and Assemblies | July 6-11, 2003 | Conference | Proctor Academy, Andover, NH, USA |
International Symposium on Bio-Organic Chemistry | February 7-8, 2000 | Conference | IICT, Hyderabad |
DST/AICTE/MHRD or Other Sponsord R&D Projects
Title of the Project | Funding Agency | Duration | Amount of Grant |
Heterocyclic-based Peptidomimetics for Non-viral Gene Delivery | SERB-DST | 2019-2022 | 41.92 |
Development of Pyrazole, Triazole and Tetrazole Based Novel Cationic lipids for Targeting Non-viral Gene Delivery to Tumors | SERB-DST Project | 2013-2016 | 31.6 Lakhs |
Development of Benzoxazole, Benzthiazole and Benzimidazoles Based Novel Cationic Amphiphiles for Non-Viral Gene Delivery Targeting to Tumors | FAST TRACK PROPOSAL FOR YONG SCIENTIST, DST | 2009-2013 | 19.32 Lakhs |
Rational Design and Synthesis of Dimerizable and Targetable Cationic Peptide Amphiphiles for Non-viral Gene Delivery | CSIR | 2007-2010 | 10 Lakhs |
Awards And Honours
Award Name | Detail |
| TAS Associate Fellow | Inducted as Telangana Academy of Sciences Associate Fellow year 2016 |
| Indo-US Fellowship | Received Indo-US fellowship Award for the year 2013. |
The Highest Impact Factor Publication Award in Chemical Science | Doctoral publication (Chem. Eur. J. 2000, 6, 2847-2853.) was cited as one of the Top Papers in Chemical Sciences published from CSIR in the year 2000. Received from the Director, IICT, for the Year 2000. |
Additional Responsibility
I/IV B.Tech Chemistry Cycle Co-ordinator
Ladies Hostel Warden
Head of the Department
Course Taught Previously |
Course Taught Previously
Academic Year | Semester | Classes | Course ID | Course Name |
2006-2007 | 1 & 2 | B.Tech | CY-101 | Chemistry |
2007-2008 | 1 & 2 | B.Tech | CY- 101 | Chemistry |
2008-2009 | 1 & 2 | B.Tech | CY-101 | Chemistry |
2009-2010 | 1 & 2 | B.Tech | CY-101 | Chemistry |
2010-2011 | 1 & 2 | B.Tech | CY - 101 | Chemistry |
| 2012-2015 | 1 & 2 | B.Tech | CY-101 | Chemistry |
| 2015-2017 | 1 | B.Tech | CY-101 | Chemistry |
2006-2007 | 4 | M.Sc | Bio-organic Chemistry | |
2007-2008 | 4 | M.Sc | Bio0organic Chemistry | |
2008-2009 | 4 | M.Sc | Bio-Organic Chemistry | |
2009-2010 | 4 | M.Sc | Bio-organic Chemistry | |
| 2011-2017 | 4 | M.Sc | CY-6152 | Bio-organic Chemistry |
2009-2010 | 2 | II B. Tech | Cy-252 | Advanced Organic Chemistry |
2010-2011 | 2 | IIBtech | CY-252 | Advanced Organic Chemistry |
2006-2007 | 3 | M.Sc | CY-604 | Chemistry of Natural Products |
2007-2008 | 3 | M.Sc | CY-604 | Chemistry of Natural Products |
2008-2009 | 3 | M.Sc | CY-604 | Chemistry of Natural Products |
2009-2010 | 3 | M.Sc | CY-604 | Chemistry of Natural Products |
2010-2011 | 3 | M.Sc | CY-604 | Chemistry of Natural Products |
| 2012-2017 | 3 | M.Sc | CY-6112 | Chemistry of Natural Products |
Courses Currently Being Taught
Classes | Department | Semester | Course ID | Course Name |
I-Btech | Chemistry | 1 | CY-101 | Chemistry |
M.Sc | Chemistry | 3 | CY-6112 |
|
| M.Sc | Chemistry | 2 | CY-5111 | Chemistry of Heterocyclics and Biomolecules |
Publications |
Journal Publication Details
Author | Title | Journal Name | Vol. Page. Year. |
Srilakshmi V. Patri*, Venkanna Muripiti, Brijesh Lohchania , Venkatesh Ravula, Shireesha Manturthi, Srujan Marepally, Amarnath Velidandi. | Dramatic Influence of Hydroxy Functionality of Azasugar Moiety in the Head Group Region of Tocopherol Based Cationic Lipids on the In-vitro Gene Transfection Efficacies. | New Journal of Chemistry
| (Under Revision). |
| Venkanna Muripiti, Ramesh Gondru, V. Patri*.
| Review of Zinc (II) scaffolds: Efficient role in gene delivery. | Chemistry Select | (Accepted). |
| Srilakshmi Patri*, Amarnath Velidandi, Venkanna Muripiti, Venkatesh Ravula, Shireesha Manturthi. | An assortment of Thiazines Preparation methods and Applications: A review. | Medicinal Chemistry Research | Submitted |
| Venkanna Muripiti, Thasneem Yoosuf Mujahid, Venkata Harsha Vardhan Boddeda, Shrish Tiwari, Srujan Kumar Marepally, Srilakshmi V Patri, Vijaya Gopal, | Structure-activity relationship of serotonin derived tocopherol lipids. | International Journal of Pharmaceutics | 2018 554: 134-148 |
| Venkanna Muripiti, Hari Krishnareddy Rachamalla, Rajkumar Banerjee, V Patri*. | a-Tocopherol-based cationic amphiphiles with a novel pH sensitive hybrid linker for gene delivery. | Organic & Biomolecular Chemistry, | 2018, 16, 2932 - 2946. |
| Venkanna Muripiti, Brijesh Lohchania, Hari KrishnaReddy Rachamalla, Srujan Kumar Marepally, Rajkumar Banerjee and Srilakshmi V. Patri*. | Tocopherol-ascorbic acid hybrid antioxidant based cationic amphiphile for gene delivery: Design, Synthesis and transfection. | Bio-Organic Chemistry,2 | 2019,82,178-191. |
| Venkanna Muripiti, Brijesh Lohchania, Srujan Kumar Marepally and Srilakshmi V. Patri*. | Hepatocellular targeted α-tocopherol based pH sensitive galactosylated lipids: design, synthesis and transfection studies. | Chem. Commun., | 2018,9, 264-274 |
Mallikarjun Gosangi, Hithavani Rapaka, Venkatesh Ravula, and Srilakshmi V. Patri. | Evolution of New â??Bolaliposomesâ?? using Novel α-Tocopheryl Succinate Based Cationic Lipid and 1,12-Disubstituted Dodecane-Based Bolaamphiphile for Efficient Gene Delivery. | Bioconjugate chemistry | 2017, 28(7), 1965â??1977. |
Mallikarjun Gosangia, Hithavani Rapakaa, Thasneem Yoosuf Mujahidb, Srilakshmi Patri*. | Novel 1, 2, 3-Triazolium Based Dicationic Amphiphiles Synthesized by using Click-chemistry Approach for Efficient Plasmid Delivery. | MedChemComm. | 2017, 8, 989-999. |
Mallikarjun Gosangi, Thasneem Yoosuf Mujahid, Vijaya Gopal and Srilakshmi V. Patri. , | Eï¬?ects of heterocyclic-based head group modiï¬?cations on the structureâ??activity relationship of tocopherol-based lipids for non-viral gene delivery. | Org. Biomol. Chem. | 2016, 14, 6857. |
Velidandi Amarnath, Prasanna Bethanamudi, Gadidasu Kranthi Kumar and Patri V Srilakshmi. | Design, Synthesis and Anti-cancer Activity of Novel Dihydropyrazole and Benzothiazole Conjugates. | Research Journal of Pharmaceutical, Biological and Chemical Sciences. | 2016, 7(3), 29-39. |
Velidandi Amarnath, Gadidasu Kranthi Kumar and Patri V Srilakshmi. | Design, Synthesis and Evaluation of Novel Benzoxazole, Benzimidazole and Benzthiazole Based Cationic Lipids as Anticancer agents. | Research Journal of Pharmaceutical, Biological and Chemical Sciences. | 2015, 6(4), 404-418. |
Kedika Bhavani, Patri V Srilakshmi.
| Benzothiazole Head-group Based Cationic Lipids: Synthesis and Applications for Gene Delivery. | Eur. Jour. of Med. Chem. | 2014, 74,703-706. |
Kedika Bhavani, Srilakshmi V Patri. | Synthesis and Gene Transfer Activities of Novel Serum Compatible Reducible Tocopherol- Based Cationic Lipids. | Molecular Pharmaceutics | 2012, 9, 1146â??1162. |
Kedika Bhavani, Srilakshmi V Patri. | The influence of minor backbone structural variations in modulating the in vitro gene transfer efficacies of tocopherol based cationic transfection lipids. | Bioconjugate Chem. | 2011, 22(12), 2581-2592. |
Bhavani Kedika and Srilakshmi V Patri. | Design, Synthesis and In Vitro Transfection Biology of Novel Tocopherol Based Mono-cationic Lipids: A Structure-Activity Investigation. | J. Med. Chem. | 2011, 54(2), 548-561 |
Velidandi Amarnath, Gadidasu Kranthi Kumar and Patri V Srilakshmi. | Synthesis of novel porphyrin based lipids and their anti bacterial activity. | Medicinal Chemistry Research | In Press |
Jeremy A. Bumer, Marquita M. Qualis, H. Dorota Inerowicz, Robert H. Haynes, V. Srilakshmi, | Cytoplasmic delivery of liposomal contents mediated by and acid-labile cholesterol-venyl ether- PEG conjugate. | Bio-conjugate Chemistry | 2009,20,47-59 |
Gollapudi Venkata Srilakshmi, Joyeeta Sen, Arabinda Chaudhuri, Yerramsetti Ramadas, Nalam Madhus | Anchor-Dependent Lipofection with Non-Glycerol based Cytofectins containing Single 2-Hydroxyethyl Head Groups. | Biochim. Biophys. Acta. (Biomembranes ) | 2002, 1559, 87-95 |
Gollapudi Venkata Srilakshmi and Arabinda Chaudhuri. | "Snap-Shooting" the Interface of AOT reverse micelles: Use of chemical trapping. | Chem. Eur. J. | 2000, 6, 2847-2853. |
Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Nalam Madhusudhana Rao and | A novel series of Non-glycerol based cationic transfection lipids for use in liposomal gene delivery. | J. Med. Chem. | 1999, 42, 4292-4299. |
Prasanta Kumar Das, Gollapudi Venkata Srilakshmi and Arabinda Chaudhuri. | Experimental probing of water and counterion concentrations inside a reversed micelle water-pool: An overlooked parameter in micellar enzymology. | Langmuir | 1999, 15, 981-987 |
PHDs Supervised |
Ph.D.'s Supervised
Candidate | Thesis | Award Year |
K. Bhavani | Awarded | |
V. Amarnath | Awarded | |
G.Mallikarjun | Awarded | |
| M. Venkanna | Awarded | |
| R. Hithavani | Soon Submitting Synopsis | |
| R. Venkatesh | In Progress | |
| M. Shirisha | In Progress |
Workshops/Conferences |
Projects |
Title of the Project | Funding Agency | Duration | Amount of Grant |
Heterocyclic-based Peptidomimetics for Non-viral Gene Delivery | SERB-DST | 2019-2022 | 41.92 |
Development of Pyrazole, Triazole and Tetrazole Based Novel Cationic lipids for Targeting Non-viral Gene Delivery to Tumors | SERB-DST Project | 2013-2016 | 31.6 Lakhs |
Development of Benzoxazole, Benzthiazole and Benzimidazoles Based Novel Cationic Amphiphiles for Non-Viral Gene Delivery Targeting to Tumors | FAST TRACK PROPOSAL FOR YONG SCIENTIST, DST | 2009-2013 | 19.32 Lakhs |
Rational Design and Synthesis of Dimerizable and Targetable Cationic Peptide Amphiphiles for Non-viral Gene Delivery | CSIR | 2007-2010 | 10 Lakhs |
Awards and Honors |
Additional Responsibility |