: chocks@nitw.ac.in : 9502205174
Research Interests: Cancer biology; Cancer cell signaling; Cancer stem cell biology
Dr. Chockalingam joined NIT Warangal as an Assistant Professor in the Department of Biotechnology in 2019. He earned his Ph.D. from the Department of Biosciences and Bioengineering (formerly Department of Biotechnology), IIT Guwahati under the supervision of Prof. Siddhartha Sankar Ghosh. His thesis work is related to the Role of Macrophage Colony Stimulating Factor in Drug Resistance. He was a postdoctoral research fellow with Dr. Karim Malik at the School of Cellular and Molecular Medicine, University of Bristol, UK where he studied the signaling pathways mediated by LGR5 in neuroblastoma. He then joined the lab of Dr. P. Gopinath at the Department of Biotechnology, IIT Roorkee where his research work involved studying the signaling pathways mediated by Cx43 gene. His current research interests include cancer biology, cancer cell signaling and cancer stem cell biology.
Academic profile:
1. Ph.D. (Biotechnology): Indian Institute of Technology Guwahati (2008-2014).
2. B. Tech (Industrial Biotechnology)- Government College of Technology Coimbatore, Anna University (2004-2008).
Positions Held:
1. Assistant Professor, Department of Biotechnology, NIT Warangal (Nov 2019- till date).
2. Post-Doctoral Fellow, Department of Biotechnology, IIT Roorkee (Nov 2017-Nov 2019).
3. Research Assistant, School of Cellular and Molecular Medicine, University of Bristol, United Kingdom (Oct 2014- Sept 2015).
4. Post-Doctoral Fellow, Centre for Nanotechnology, IIT Roorkee (May-Sept 2014).
5. Project Trainee, Molecular Pathogenesis Lab, Department of Microbiology and Cell Biology, IISc Bangalore (Dec 2007- June 2008).
6. Summer Research Fellow, Bacterial Genetics Lab, CDFD Hyderabad (May 2007-June 2007).
Course Taught Previously |
Engineering Biology
Immuno Technology
Animal Biotechnology
Molecular Biology and Genetics
Cancer Biology
Animal Biotechnology Laboratory
Cell Biology Laboratory
Publications |
In SCI/SCIE indexed journals:
12. S Chockalingam, G Packirisamy, R Paulmurugan. Nanomaterials for targeted delivery of therapeutic and imaging agents. Front Cell Dev Biol. 2022 Aug 5;10:978690.
11. S Jindal, S Chockalingam, SS Ghosh, P Gopinath. Connexin and gap junctions: Perspectives from biology to nanotechnology based therapeutics. Translational Research. 2021, 235, 144-167.
10. Sarim Khan, Sankarakuttalam Chockalingam, Patit P Kundu, Gopinath Packirisamy. Fabrication of bimodal porous scaffold with enhanced mechanical properties using silanized sisal fibers for potential application in bone tissue engineering. Mater. Today Commun. 2020, 25: 101260.
9. Mehak Passi, Sadia Shahid, Sankarakuttalam Chockalingam, Isaac Kirubakaran Sundar, Gopinath Packirisamy. Conventional and Nanotechnology Based Approaches to Combat Chronic Obstructive Pulmonary Disease: Implications for Chronic Airway Diseases. Int J Nanomedicine. 2020 May 28;15:3803-3826.
8. Khan S, Garg M, Chockalingam S, Gopinath P, Kundu PP. TiO2 doped chitosan/poly (vinyl alcohol) nanocomposite film with enhanced mechanical properties for application in bone tissue regeneration. Int J Biol Macromol. 2020 Jan 15;143:285-296
7. Raj Kumar Sadasivam, Chockalingam Sankarakuttalam and Gopinath Packirisamy. Hierarchical Architecture of Electrospun Hybrid PAN/Ag-rGO/Fe3O4 Composite Nanofibrous Mat for Antibacterial Applications. Chemistryselect. 2019; May; 4(17):5044-54.
6. Asif Raza, Archita Ghoshal, S. Chockalingam & Siddhartha Sankar Ghosh. Connexin-43 enhances tumor suppressing activity of artesunate via gap junction-dependent as well as independent pathways in human breast cancer cells. Sci Rep. 2017; Aug 8;7(1):7580. (Nature publishing group)
5. S. Chockalingam* and Siddhartha Sankar Ghosh. Macrophage colony-stimulating factor and cancer: a review. Tumor Biol. 2014 Nov;35(11):10635-44. (* Corresponding author).
4. Shilpa Sharma, S. Chockalingam, Pallab Sanpui, Arun Chattopadhyay and Siddhartha Sankar Ghosh. Silver Nanoparticles impregnated Alginate-Chitosan blended Nanocarrier Induces Apoptosis in Human Glioblastoma Cells. Adv Healthc Mater. 2014 Jan;3(1):106-14. doi: 10.1002/adhm.201300090.
3. S. Chockalingam and Siddhartha Sankar Ghosh. Amelioration of Cancer Stem Cells in Macrophage Colony Stimulating Factor-Expressing U87MG-Human Glioblastoma upon 5-Fluorouracil Therapy. PLoS ONE. 2013; 8(12): e83877. doi:10.1371/journal.pone.0083877.
2. Navjot Kaur, Nitin Choudhary, Rajendra N. Goyal, S. Viladkar, I. Matai, P. Gopinath, S. Chockalingam, Davinder Kaur. Magnetron sputtered Cu3N/NiTiCu shape memory thin film heterostructures for MEMS applications. J Nanopart Res. 2013; 15:1468.
1. Debashree Saikia, Naba K. Bordoloi, Pronobesh Chattopadhyay, S. Chockalingam, Siddhartha S. Ghosh, Ashis K. Mukherjee. Differential mode of attack on membrane phospholipids by an acidic phospholipase A2 (RVVA-PLA2 -I) from Daboia russelli venom. Biochim Biophys Acta. 2012 Dec;1818(12):3149-57.
In Scopus indexed journals:
1. Vieira, G.*, Chockalingam, S*., Melegh, Z., Greenhough, A., Malik, S., Szemes, M., Park, J.H., Kaidi, A., Zhou, L., Catchpoole, D., Morgan, R., Bates, D.O., Gabb, P. and Malik, K. LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma. Oncotarget. 2015; Nov 24;6(37):40053-67. (* Joint first authors).
Book chapters:
1. S Bhattacharyya, K Sandhu, S Chockalingam. Nanotechnology-based healthcare engineering products and recent patents—an update. Emerging Nanotechnologies for Medical Applications, 2023, 273-296. (Publisher: Elsevier).
PHDs Supervised |
Ongoing:
1. Ms. Kajal (Jan 2021 onwards)
Workshops/Conferences |
FDPs/Workshops/Conferences organized:
1. Five-day online FDP on “Emerging Trends in Biotechnological Advancements: Challenges and Prospects in Tackling Human Diseases”, 13-17 July 2020.
Conference presentations:
1. Chockalingam Sankarakuttalam, Gabriella Cunha Vieira, Marianna Szemes, Sally Malik, and Karim Malik. LGR5 is a regulator of survival and proliferation of neuroblastoma cells. 9th Mammalian Genes, Development and Disease Meeting 2015, University of Bath, United Kingdom. (Oral presentation).
2. S. Chockalingam and Siddhartha Sankar Ghosh. Macrophage Colony Stimulating Factor (MCSF) Increases the Resistance of Glioma Cells to 5-fluorouracil Through Formation of Cancer Stem Cells. Cancercon 2014, International Conference in Cancer Biology: Molecular Mechanisms and Novel Therapeutics, Indian Institute of Technology Madras, India. (Poster presentation).
3. Shilpa Sharma, S. Chockalingam, Arun Chattopadhyay and Siddhartha Sankar Ghosh. Induction of Apoptosis in Human Glioblastoma Cancer Cells at Low Silver Nanoparticle Concentration Using Alginate- Chitosan Blended Nanocarrier. Frontiers in Chemical Sciences (FICS) – 2012, Indian Institute of Technology Guwahati, India. (Poster presentation).
4. S. Chockalingam and Siddhartha Sankar Ghosh. Overexpression of MCSF Increases the Sensitivity of Human Glioblastoma Cells to 5-fluorouracil. 3rd International Conference on Stem Cells and Cancer (ICSCC- 2012): Proliferation, Differentiation, and Apoptosis, New Delhi, India. (Oral presentation).
5. S. Chockalingam and Siddhartha Sankar Ghosh. Macrophage Colony Stimulating Factor (CSF-1) Expression Potentiates 5-fluorouracil Sensitization of Drug Resistant Cancer Cells. UICC-World Cancer Congress 2012, Montreal, Quebec, Canada. (e-Poster presentation).
Additional Responsibility |
Journals:
Institute level responsibilities: